Real Madrid have lost Gonzalo Higuain and Sami Khedira for tomorrow's Champions League clash at Ajax.

Argentina striker Higuain, who played 76 minutes of Saturday night's 5-1 win over Athletic Bilbao and scored the opening goal, is struggling with a back problem while German midfielder Khedira, who was replaced in the 67th minute, has a hamstring strain.

Madrid have already secured their place in the last 16 of the Champions League but could guarantee themselves top spot in Group G if results go their way this week.

Jose Mourinho's side are currently five points clear of second-placed AC Milan while Ajax are a further point back.

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