Ronaldo hit another treble in the 4-1 win.
Ramos said: "The squad is strong, excited and driven... It would be a shame to let this title slip through our fingers after the great effort and sacrifices we've made all season.
"We don't think Barcelona are going to drop many points, but we depend on ourselves and our four point cushion allows us to keep up the good work.
"Cristiano Ronaldo is the best player in the world. We're lucky to train with him every day and to have him with us."