On Tuesday night, they travel to arch rivals Barcelona for the second leg of their Copa semi-final, while next Tuesday they will be at Old Trafford for the second leg of the Champions League last-16 tie with Manchester United.
Both ties are delicately poised at 1-1 after first legs in Madrid.
If that was not enough to get the juices flowing in the Madrid squad, there is the small matter of another Clasico in the league when Barca come in the opposite direction on Saturday evening.
"These are the sort of matches that we like to play, that everyone wants to play," Mourinho said.
"I prefer matches that are this difficult. We are ready and we are all looking forward to playing these big matches."