Mourinho declared it "impossible" after Real fell 13 points behind Barcelona.
He declared: "No, I've never seen a situation like this where I have lost that many points and my team was so far from its aims, in this case the league. It is a new situation for me but I do not make a big drama about it. It is a new stage in my career and I will try to do my best.
"I do not lack the strength to try my best until the end of the season. We have titles to fight for. The league title seems almost impossible, but we must continue because Real Madrid demands that pride and professionalism to always try to do your best and to win. But in all my years of coaching we have always or almost always met our targets and therefore this is a new situation for me."