Benzema took his tally to four goals in three LaLiga games with a brace in Saturday's 4-1 win over Leganés at the Santiago Bernabéu.
"Why not?" Lopetegui said when asked about Benzema's chances.
"Why shouldn't he finish with 30 or 40 goals? The most important thing is the team and goals are the work of the whole team. Benzema is a great player and always has been. What he's doing is credit to him. He's happy and is helping the team, and it'll stay like this."