The clash is the pick of the knockout round.
"This will be an excellent match for the fans. For the players, playing a great team and prestigious organization like Manchester is a special source of motivation. We hope to go into the match in good condition, with all of our players fit and full confidence in our team," said Butragueno.
"It is exciting for the fans, for the players and for the club. Facing Manchester United is an extra motivation and you have to make the most of that. You have to prepare and play well."