The Castilla warmed up for the game with a 5-0 win over Villarreal B on Sunday.
"It's a match that adds a touch of greatness to the division," said Juanfran.
"It's the best match of the season in the Second Division. We will do our best to come away with all three points. The game we played in the first half of the season was really good and the whole team enjoyed themselves. It was important for us."