The Italians became the seventh European team to fail to find the back of the net at Ibrox this season when they were held to a goalless draw in the semi-final first leg in Glasgow on Thursday night.
Smith is now hoping history will repeat itself in Florence next week, with 90 minutes of football standing between Rangers and a meeting with Bayern Munich or Zenit St Petersburg at Eastlands on May 14.
"We have been drawn at home first in every tie that we've had this season both in the Champions League and UEFA Cup," Smith said.
"If you don't concede the away goal, you're always in with a chance when you go away from home. Not conceding the away goal gives us that opportunity.
"We can take a bit of confidence from the away games that we've played this season. In the Champions League we have managed to score away from home against Stuttgart and Lyon, and we have scored away from home in Lisbon and Panathinaikos [in the UEFA Cup].
"I don't think any of these places are places teams would relish going having to win a game.
"But we have managed to go and score there so, as the season has gone on, we have gained a confidence in the away games and we take that confidence to Florence next week."