Lyon are in Madrid defending a 1-0 lead from the first-leg.
"The team is very upbeat. We can win La Liga and the Champions League. We are lucky that we control our own destiny," Ramos told Marca.
"Lyon will fall back to defend, close its lines and try to prevent us from finding room to work with. We will try to move the ball around quickly so that the field opens up and we can find open spaces.
"This kind of match motivates all players involved because there is so much at stake.
"We are going to win 3-0 and the fans are going to enjoy watching."