The R’s make the short trip to White Hart Lane on Sunday with Hughes struggling to put together a cohesive back four due to a number of injuries.
"We have got a number of injuries at the back, unfortunately," the QPR manager said.
"Anton is not going to be available, although [his hamstring injury] is actually settling down a little bit quicker than we thought initially.
"That is good news but he is not going to be available this weekend and Fabio is going to be out for a number of weeks, which is a blow.
"To compound that, Armand Traore is not available either because of injury so we're going to have to move people around to compensate for that.
"Samba Diakite is not ready to be involved at first-team level yet. He needs a little bit more conditioning work to be ready for the Premier League.
"Stephane is not ready either. He still has a little bit of discomfort from the injury he picked up on international duty.”