Pulis believes Stoke fans will enjoy seeing Los Che's stars.
"I can tell you that our supporters will see some top, top players when Valencia come to town," Pulis told The Sentinel.
"We've had some great results in Europe this season, particularly at our place, but this opposition is a step up from what we've faced so far.
"They've got players from Brazil, Italy and Argentina. They are technically very good, well drilled, powerful and prepared to work hard as well.
"They are a Champions League team, really, and the third-best team in Spain, but are not too far behind Barcelona and Real Madrid."