Manchester United move four points clear of Arsenal at the top of the Premiership, Wolves move out of the relegation places, but Blackburn's slide down the table continues. Manchester United have now won all 13 games played against Wigan following an emphatic 4-0 win at the DW Stadium.
Javier Hernandez scored early for the visitor's before three goals in the final 16 minutes eased United to three points.
The Mexican striker slotted a cool second 15 minutes from time to make it nine league goals from eight starts followed by a Wayne Rooney tap-in and substitute Fabio added the fourth.
For lowly Wigan they remain in the bottom three and a struggle to retain their Premiership status.
Aston Villa eased their Premier League relegation worries and made it one defeat in their last seven games as they easily overcame a disappointing Blackburn 4-1 at Villa Park.
Rovers have now lost seven of their last eight away games and are now glancing nervously over their shoulders towards the drop zone.
To end a miserable afternoon for the men from Ewood Park, New Zealand international Ryan Nelsen saw red late-on.
It was a scoreless at half-time but Villa were rampant after the break.
Ashley Young's penalty put Villa ahead then Marc Albrighton's low cross went in off Rovers defender Grant Hanley.
Stewart Downing made it three before the visitor's threatened a revival as substitute Nikola Kalinic's reduced the deficit only for Young to get his second of the afternoon.
Kieran Richardson had an early opportunity for the visitor's and Stephane Sessegnon hit the woodwork but overall the Black cats offered little to trouble the Toffees who continue to pull away from the wrong end of the table.
Ten-man Newcastle had to settle for a point against Bolton after losing Ryan Taylor to a second-half dismissal.
The hosts had dominated after Kevin Nolan headed on 13 minutes but Chelsea loanee Daniel Sturridge fired the Wanderers level before the break for his fourth goal in four games.
Bolton however rarely looked like making their numerical advantage count.
Newcastle now have the unusual record of not having won a Saturday Premier League home match that kicked off at 3.00pm since August 2008.
Wolves move out of the bottom three on goal difference after a massive 3-0 home win over Blackpool who themselves are slowly being dragged into a relegation battle.
The home side had the perfect start with a goal after two minutes from Matthew Jarvis.
The Tangerines cause was then not helped as DJ Campbell was sent off late in the first half for raising his hands at Richard Stearman.
And the hosts took full advantage thanks to Jamie O'Hara's fine low shot and two late Sylvan Ebanks-Blake strikes.