The Blues may have failed to score six for a third successive game but they proved too classy for the Potters.
Frank Lampard saw his weak penalty easily saved by Thomas Sorensen before Florent Malouda opened the scoring at Stamford Bridge.
Glenn Whelan for Stoke and Ashley Cole for the home side both hit the woodwork.
From Chelsea’s second spot kick of the afternoon Didier Drogba wrapped up a comfortable three points for the defending champions.
Wigan stunned Tottenham who were clearly still revelling in qualifying for the Group Stages of the Champions League.
The Latics suffered a 9-1 hammering last season but this time a late strike from Hugo Rodallega proved enough in a 1-0 win over a lacklustre Spurs.
Jermaine Defoe went close for the home side but Wigan centre back Steve Gohouri hit the cross bar early on.
Arsenal emerged with the three points at a rain-soaked Ewood Park, winning 2-1.
Andrey Arshavin scored the winner early in the second half after Theo Walcott’s first half opener had been cancelled out by Mame Diouf’s quick reply.
The visitor’s took the lead in the first half through Bobby Zamora in front of watching England coach Fabio Capello.
Then all the action happened in the closing stages of the second half.
A John Pantsil own goal gifted the Seasiders a leveller and five minutes later the home side took the lead through on-loan striker Luke Varney.
But Fulham rallied three minutes from time and Dickson Etuhu spared the Cottagers blushes with an equaliser.
Newcastle went behind at Wolves but rallied in the second half to force a 1-1 draw.
The home side punished the Magpies for missing several first-half chances with Sylvan Ebanks-Blake firing home shortly before the interval.
But Andy Carroll followed up his recent hat-trick to secure a point at Molineux with a header from Joey Barton’s free kick.