They will compete against for the Barclays Asia Trophy, which will take place between 24-27 July in the former Principality.
Spurs boss Andre Villas-Boas said: "The club is delighted to have the opportunity to return to Hong Kong and play in the 2013 Barclays Asia Trophy.
"Over the past few years, we have seen a significant increase in the levels of support the club has across the region.
"This tournament presents us with an opportunity to thank those fans, as well as introducing new fans to Tottenham Hotspur.
"We are also delighted to have the chance to compete alongside South China FC - a club with which we already enjoy a special relationship."