At Old Trafford, Robin van Persie scored his 16th goal of the domestic season in the 19th minute before Nemanja Vidic added a second ten minutes into the second half prior to winter signing Daniel Sturridge scoring his first league goal for the fast-finishing Reds.
At the Emirates Stadium, the Gunners lost defender Laurent Koscielny to an early red card before James Milner and Edin Dzeko put City two goals ahead but City also finished the game with ten men with Vincent Kompany copping a questionable sending off with 15 minutes remaining.
Everton retained fifth spot with a 1-1 draw at home against Swansea City as Southampton stretched their unbeaten streak to four matches with a 1-0 victory to heap more misery on 18th-placed Aston Villa.
Reading moved two points off the bottom with a 3-2 triumph at home over West Bromwich Albion despite conceding twice to Romelu Lukaku before scoring three times in the final eight minutes to complete an amazing comeback.
In the assists column, Liverpool skipper Steven Gerrard and Chelsea ace Juan Mata lead the way on eight with United striker Wayne Rooney behind them on seven whilst van Persie, Arsenal pair Lukas Podolski and Theo Walcott, Chelsea’s Eden Hazard and Fulham’s Bryan Ruiz all sit on six.
2012/13 Barclays Premier League season scores
Fulham: 1 (Giorgos Karagounis 22’)
Wigan Athletic: 1 (Franco Di Santo 71’)
Craven Cottage, London – 25,442