Tottenham pulled off an amazing comeback over Arsenal with a 3-2 victory after being two goals down, and Manchester United easily disposed of nine-man Wigan. Samir Nasri and Marouane Chamakh put the Gunners in the driving seat by half-time.
But Gareth Bale began the fightback before Rafael van der Vaart's levelled from the penalty spot.
And Younes Kaboul sealed an unlikely three points for Spurs as he headed home a dramatic late winner.
Defending Premier League champions Chelsea's miserable away form continued with a 1-0 defeat at Birmingham, to lose for the third time in four matches.
Lee Bowyer goal in the 17th minute proved sufficient and whilst Chelsea threw everything they had at Birmingham, they found keeper Ben Foster in inspired form.
Patrice Evra opened the scoring on the stroke of half-time and Wayne Rooney made his long awaited comeback to a standing ovation in the 56th minute.
Three minutes later Wigan were reduced to ten men when Antolin Alcaraz was shown a second yellow card then Hugo Rodallega quickly followed with a straight red.
Substitute Javier Hernandez made it 2-0 when nodding into the back of the net.
Owen Coyle's Bolton moved into the top four with a 5-1 win over Newcastle at the Reebok Stadium.
Kevin Davies opened the scoring from the penalty spot after former Wanders hero Kevin Nolan had handled.
Chung-Yong Lee doubled the home side's advantage just before the break.
Johan Elmander made it three then Andy Carroll reduced the deficit for Newcastle.
Elmander then added his eighth goal of the season in the 72nd minute, before Fabricio Coloccini's dismissal for elbowing the Swede.
Davies then scored his second penalty to complete a miserable day for the Toon.
Wolves remain in the relegation mire after losing to Blackpool for the first time in fifteen meetings, 2-1 at Bloomfield Road.
Luke Varney's fantastic 30 yard effort put the host's in front and this was doubled on half-time by Marlon Harewood.
Kevin Doyle's first league goal of the season set up a tense last four minutes, but Wolves could not find an equaliser.
All the goals in the midlands derby at West Brom came in the second half were visitor's Stoke triumphed 3-0, helped by two penalties.
Two goals in the final five minutes, both from substitute Jon Walters, one from the penalty spot enabled Stoke's to maintain their incredible statistic of scoring 87% of their goals in the second half.