The Hammers opened the scoring through Kevin Nolan in just the first minute when he was able to fire home from close range after new signing Andy Carroll had been involved with a head flick-on into the path of Ricardo Vaz Te who found the skipper.
The score was then 2-0 prior to the half-hour mark when defender Winston Reid got on the end of Matt Taylor's corner to finish with a header from the edge of the six-yard box.
A clinical West Ham then found themselves three ahead with four minutes left in the first half when Taylor picked up a loose ball from a clearing Brede Hangeland header to finish neatly from near the penalty area.
Carroll was making his debut for the Hammers after joining on loan from Liverpool and won almost every header which came his way before coming off after the hour-mark with a groin injury whilst Dimitar Berbatov made his first appearance for Fulham after his move from Manchester United, coming on at half-time, and having some influence on the game late.
Nevertheless, Sam Allardyce would be thrilled with his side as they picked up their second win from two home outings whilst Martin Jol's Cottagers slumped to a second successive defeat after losing 3-2 at United last week.
Upton Park, London - 33,458
Yellow cards:WHU - nil FUL - nil