At half-time it appeared to be a strange move from the great manager but as always he was vindicated with his selection process as United scored four times in the second half to notch up their third victory of the new campaign.
Veteran midfielder Scholes marked his milestone game with the opening goal in the 51st minute when he tapped in from close range when Nani's cross from the right caused some confusion in the box before Javier Hernandez, who had earlier missed a penalty, added a second just over 10 minutes later.
The Mexican was on hand to deflect Buttner's goalbound attempt into the back of the net to put United in the driver's seat.
Another United new boy in Nick Powell also got himself on the scoresheet when he came off the bench to make it 4-0 with eight minutes remaining with a well-struck effort from range.
Early on, United were awarded a questionable penalty when Danny Welbeck went down under minimal pressure from Latics goalkeeper Al Habsi with the Omani able to deny Chicharito from the spot. It is believed that Welbeck will face calls for diving with the incident set to be reviewed this week.
Nevertheless, it was a stellar second-half performance from Ferguson's men who are now second on the table, just one point behind Chelsea as Wigan drop to 13th with their second defeat of the season.
Old Trafford, Manchester - 75,142