Seven English clubs will compete in European competition this season as the reputation of football in the UK is once again on the line.
In the Champions League, Chelsea will be favoured to go a long way under Jose Mourinho while Manchester United make their much anticipated return (pending their play-off) to Europe's premier club competition.
Arsenal are present again but can Arsene Wenegr guide them past the Round of 16? And will Manchester City improve on their recent first round knockout exits?
In the Europa League, Liverpool will be determined to succeed back on the European stage but will it effect their league ambitions?
Tottenham and Southampton will also do battle in the second tier as English football looks to make their presence felt after a couple of lean seasons on the mainland.
CHAMPIONS LEAGUE
The reigning Premier League champions will enter this season's Champions League competition full of confidence after rediscovering their mojo under Jose Mourinho last season.
The Blues have managed to keep the majority of their squad from the previous campaign and that continuity is sure to pay dividends when the rigours of juggling European competition with a Premier League title defence inevitably begin to take their toll.
Chelsea have added depth in the striking department with Radamel Falcao hopeful of reclaiming his pre-Manchester United form and providing adequate support up front for Diego Costa and Loic Remy.
The departure of Champions League winning goalkeeper Petr Cech is a big loss for the Blues, however the signing of Asmir Begovic from Stoke City will provide good cover for expected number one Thibaut Courtois.
Chelsea's first XI will once again feature the likes of John Terry, Gary Cahill, Branislav Ivanovic, Cesc Fabregas, Eden Hazard and Costa – all world class players capable of carrying the Stamford Bridge outfit deep into the knockout stage of the tournament.
Chelsea last tasted Champions League success in 2012 and this campaign may prove to be their best opportunity since then to match that achievement.
At the very least, Mourinho will be expecting a much better showing in Europe than last season, where the Blues where bundled out of the tournament in the Round of 16 by Paris Saint-Germain.
Arsene Wenger's men have broken a nine-year trophy drought with back-to-back FA Cup wins the past two seasons, and now they have the taste for silverware, who's to say the Champions League title is not the next item on their agenda?
The Gunners have some of the most creative young talents in world football in the likes of Jack Wilshere (although sidelined by injury again), Danny Welbeck, Theo Walcott, Alex Oxlade-Chamberlain and Aaron Ramsey.
If these rising stars can find the consistency required to balance domestic competitions with European commitments, Arsenal are capable of matching it with the continent's best clubs.
The arrival of Champions League winner Cech between the sticks adds a level of experience to Wenger's squad, and instantly makes Arsenal's back four appear much more secure and formidable.
If North London's pursuit of Real Madrid striker Karim Benzema comes to fruition, the Gunners will gain a goal scorer who has conquered all before him with Los Blancos.
Arsenal have sees their past five Champions League campaigns ended in the Round of 16.
The challenge for Wenger is replicate the same mentality his squad used to conquer all in the sudden death environment of the FA Cup the past two seasons and apply it to the knockout stages of the Champions League.
Suffice to say, Manchester City's performances on the continental stage since the Abu Dhabi United Group's takeover of the club have been somewhat underwhelming.
City have qualified for the past four Champions League tournaments, but are yet to progress beyond the Round of 16.
It would be unsurprising if City were to make a deep run in the Champions League this season their top priority and they certainly have the squad and resources to do so.
The addition of former Liverpool winger Raheem Sterling and the potential signing of Wolfsburg's Kevin De Bruyne adds more depth to what was already an embarrassment of riches in the front third for manager Manuel Pellegrini.
An errant back four continues to be City's main hurdle for Champions League success however, with the defensive errors that plagued the side last season once again liable to be punished by classier European opponents.
The roles of goalkeeper Joe Hart and captain Vincent Kompany in ensuring City are functioning, as a cohesive defensive unit cannot be overstated enough.
On paper though, City have the talent and depth to match it with any team on the continent and if Pellegrini can get his troops firing on all cylinders, this may be the season where City when their first European title.
After finishing fourth in the Premier League last season, the Red Devils must qualify for the Group Stage of the tournament via a play-off.
They will know their opponent for the crucial two-leg home and away tie following the Champions League playoff round draw on Friday.
After two lacklustre Premier League campaigns by their own standards, United's exuberant spending during the summer transfer window has made clear their intention to make a swift return to the glory days and dominance they enjoyed under Sir Alex Ferguson.
United's big-name off-season acquisitions include Memphis Depay (PSV), Matteo Darmian (Torino), Bastian Schweinsteiger (Bayern Munich) and Morgan Schneiderlin (Southampton).
Louis van Gaal has made a concerted effort to increase United depth across the park this off-season and has brought an exciting mix of young talent and experience to Old Trafford.
This type of recruitment should hold the Red Devils in good stead for a successful European sojourn this season, although they still must negotiate the potential banana skin that is the play-off round.
It is almost unfathomable to think of Manchester United-less Champions League tournament for the second year in a row, but if the Red Devils somehow fail to qualify for the group stage, it's hard to see van Gaal making the Europa League a priority.
If that scenario plays out, expect van Gaal to focus all his attention on United's Premier League campaign and use the Europa League fixtures as an opportunity to blood young talent.
EUROPA LEAGUE
Tottenham
Spurs are preparing for their fifth consecutive Europa League campaign and will be hopeful of improving on their performance from last season, which saw them eliminated in the Round of 32.
Tottenham have had a relatively quiet summer, with Kevin Wimmer (Cologne), Kieran Trippier (Burnley) and Toby Alderweireld (Atletico Madrid) the only notable acquisitions made by Mauricio Ponchettino.
On a positive note, the Argentine has retained a number of key players from last season's squad, with the prolific front three of Christian Eriksen, Nacer Chadli and Harry Kane picking itself.
The concern is the lack of options beyond that trio, especially the absence of a proven goal scorer if Kane gets injured or is unable to replicate his scintillating form of the 2014/15 campaign.
One expects Tottenham to take a wait and see approach in relation to the Europa League, with their standing in the Premier League expected to have some type of bearing on the line-ups that take the field on European nights.
A favourable draw in the group stage and dominant performances to match, could see Spurs go all-in for a tilt at European glory once the knockout phase begins.
However, a lacklustre start could just as easily result in Tottenham throwing the continental competition to the side in a bid to focus on the gruelling Premier League schedule and a top-four finish.
Much has been made of Liverpool's now decade-long quest for a major trophy (no, we are not including their League Cup triumph in 2011/12!) and many suggest the Europa League title is an attainable piece of silverware for the Anfield club.
Whether Brendan Rodgers and his men see it that way remains to be seen, with question marks lingering over whether the Reds have the squad depth to juggle domestic fixtures with European commitments.
It is likely Liverpool's primary focus will be a top-four finish in the Premier League, although their activity during the transfer window appears to have significantly bolstered their line-up.
Among the raft of new signings are Christian Benteke (Aston Villa), James Milner (Manchester City), Danny Ings (Burnley), Adam Bogdan (Bolton), Joe Gomez (Charlton), Roberto Firmino (Hoffenheim) and Nathaniel Clyne (Southampton).
Much of their success in the Europa League this season will hinge on Benteke's ability cure the hangover still being felt by Luis Suarez's departure from the club.
Keeping the likes of Daniel Sturridge injury free is also crucial, if the Reds hope to successfully battle for silverware on multiple fronts.
New signings Firmino and Milner will be key players in Rodgers' system, while Philippe Coutinho and Adam Lallana must begin to perform at a consistently high level each time they take the field.
The style of play employed by Rodgers is well suited to European competitions, but the former Swansea boss will need every play at his disposal fit and firing if Liverpool are to battle for silverware on multiple fronts this campaign.
The Saints progressed to the Europa League play-offs with a comfortable 5-0 aggregate win over Dutch outfit Vitesse Arnhem in the third qualifying round.
Their opponent for the final knockout phase will be drawn on Friday.
Koeman was unable to guide Feyenoord past the Europa League playoff stage in two attempts with his former club and it appears a lack of squad depth may prove to be his biggest challenge with Southampton.
The departures of Morgan Schneiderlin (Manchester United) and Nathaniel Clyne (Liverpool) leave the Saints without two of their key players from last season, but Koeman appears to have done well in recruiting their replacements.
Schneidelin's replacement, Jordy Clasie, is a known quantity to Koeman from their time together at Eredivise club Feyenoord.
The 24-year-old appears to have a strong pedigree, having already made 11 appearances for the Dutch national team, while also being a key member of Feyenoord's progression to the Round of 32 in last year's Europa League.
Similarly, it appears Southampton have done their due diligence in recruiting Cedric Soares from Benfica as to fill the void left at right-back left by Clyne.
The experience Soares gained during the Portugese club's Champions League campaign last season is also likely to benefit Southampton' cause.
Should Southampton progress through to the group stage of the tournament, one expects they may find it difficult to go any further than that, despite their seemingly astute recruitment.
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