Premier League managers will be free to select whatever line-up they wish for the coming season.
Both Blackpool and Wolves have fallen foul of Premier League rule E.20, which states that "in every league match, each participating club shall field a full-strength team".
The league has now relaxed that rule, meaning managers will be free to choose at will from their senior squad and, if need be, their pool of 'home-grown' under-21 talent.
A spokesman for the Premier League said: "The clubs voted at the last Premier League Annual General Meeting to modify the rule regarding clubs fielding full strength teams (E.20).
"From 2011-12, onwards the rule will allow any combination of players included in a club's 25-man squad list to be selected for a Premier League fixture.
"The 25-man squad rules do allow clubs to pick Under-21 players beyond those named in their squad list and, with this in mind, it was agreed by the clubs that it was appropriate for the rule to remain in place in order to ensure the integrity of the competition."
