After 15 highly successful seasons, the top flight is about to enter a new era with Setanta joining Sky as broadcast partners and talkSPORT gaining a share of the radio rights from BBC Five Live.
With overseas contracts and other packages, the Premier League will rake in almost £2billion over the next three years.
Yet Scudamore, whose tenure was largely viewed as an unqualified success until the Carlos Tevez affair emerged, believes the league is now so well established, it can survive the loss of any individual.
"You lose a Henry but you gain a (Fernando) Torres," reflected Scudamore.
"Thierry Henry has been fantastic for the Premier League. We were cheering last year when he stayed and now we are disappointed he has gone because he is a stellar player.
"But it is only a few years ago we lost David Beckham. Other players come in their place.
"It really has got to a level now where we are attracting the world's top talent right at the top of their game. No one individual could leave this league tomorrow and make a big difference to our attractiveness."