Saints will meet with Arsenal this weekend.
"I rate Mesut Ozil as one of the top 10 players in the world," he said of the former Real Madrid playmaker.
"It is clear they are two great football players. It is clear that you cannot afford to grant them any space or time to think because they are players with individual actions can decide a game on their own.
"They are amazing talents as we saw in La Liga and now as we see in the Premier League, so we have to be really careful with the two of them."
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