Totti's absence has coincided with Roma's run of draws in recent games.
"Totti is something special for Roma," midfielder Pjanic told Sky Sport Italia.
"It's not easy to play without Totti. When he's not here, the team plays differently, as we are missing out strongest element.
"I won't say we lose confidence without him, but we are accustomed to always having him on the field. When he's not there, we are missing a reference point. All the play goes through him, so Roma have to play differently without Totti.
"He is an important player, certainly, but despite all that we proved that we can do well without him."
For breaking stories and all the great banter like us on Facebook: facebook.com/tribalfootball