Guidolin reckons victory over Atalanta today would assure their top-flight status.
"If we were to achieve victory this weekend, then it would practically secure safety for Parma," said Guidolin.
"For now we must focus only on overcoming Atalanta as if it were a Cup Final. It's important because we are facing a side that is absolutely desperate for points in every game.
"Therefore we must adopt the same attitude. We know we're not too far from our objective and that a win could well put our Serie A status under lock and key two months early.
"We need to match Atalanta's level of motivation, as often that can make the difference."