Palermo chief Walter Sabatini admits Simon Kjaer's future is likely to be in England.
Manchester United, Manchester City and Tottenham have all been linked with the Denmark defender this week.
"If Milan cannot keep Kaka, and Inter cannot hang on to [Zlatan] Ibrahimovic, then how can Palermo keep their best players? It would not be a redimension," Sabatini told Corriere Dello Sport.
"Where will they [Kjaer and Edinson Cavani] go? I say the Premier League."
Uruguay striker Cavani has been linked with West Ham United.