Crystal Palace boss Neil Warnock accepts he's likely to sell his top youngsters in the summer.
Right-back Clyne, 17, went home with the sponsors' man-of-the-match award while winger Moses, 18, ripped the Reading defence apart.
Warnock said: "They could be the future of the club, but we're not going to be able to keep hold of them for much longer.
"You're talking about top-four players. I've not had a young defender better than Nathaniel since I've been a manager.
"Victor used to only play when he wanted - but we've pushed him and he's no longer a luxury, he contributes to the team.
"Neither of them will leave unless we're offered silly money."