Madrid have won 14 successive matches at the Bernabeu stretching back to last season, while they are averaging four goals a game in their last eight appearances in front of their own fans.
Sevilla, in contrast, are in a major rut.
They have lost four on the trot in La Liga to fall down to 11th in the standings, and in their last six competitive matches have suffered five defeats and picked up one draw.
Nevertheless, Madrid are not expecting an easy evening against a side who have finished in the top five in each of the last five seasons.
Ozil said in AS: "Our concentration needs to be very high. Every team wants to beat Madrid, so it's going to be a very difficult game."