The Blues go into the match against Liverpool without star goalscorer Tim Cahill but Osman is supremely confident that David Moyes' men can make up for the absence of the Australia international.
Everton defeated the Reds earlier this season and since then, the problems at Anfield have only gotten worse and Osman says the Toffees are ready to pounce.
"We're aiming to do the double in the derby matches this season. What's happening with them off the field, and the management issues don't concern us at all," he told the Liverpool Echo.
"We've got to concentrate on ourselves and make sure our form is right, and we turn up on the day ready to take three points.
"Possibly we'll miss Tim Cahill. But he has been away for two games now and we've won them both. Were not in any way sitting and being upset about him not being here."