Osasuna are set to lose Savo Milosevic, Inaki Munoz and Valdo at the end of the season.
Milosevic is departing as he comes off contract next month, while Munoz is also leaving after failing to agree terms over a new deal with Osasuna management on Wednesday.
Winger Valdo is being offloaded after refusing a new contract offer made by Osasuna some months ago.
Meanwhile, Javier and Miguel Flano have both signed new deals with Osasuna. Javier will be a Rojillo until June of 2009 and his brother, until 2010.