It will be a match which will mark the Premier League bow of the Gunners' new Spanish boss Unai Emery.
City, who amassed 100 points and 106 goals en route to finishing 19 points clear of Manchester United in 2017/18, do not face another top six side until the trip to Liverpool in October. Games against newly-promoted trio Wolves, Cardiff and Fulham are part of a sequence which also includes Huddersfield, Newcastle and Brighton - the three teams who came up the previous season.
It is a similar story for neighbours United, who begin at home to Leicester City. The 2017/18 runners-up have Tottenham at home in their third game, with Brighton, Burnley, Watford, Wolves, West Ham and Newcastle are their other early season opponents.
Liverpool's start appears more challenging. After hosting West Ham, Jurgen Klopp's men face Tottenham, Chelsea and Manchester City in a run which also includes Crystal Palace, Brighton, Leicester and Southampton.
Tottenham, who have until Friday to decide whether to return to Wembley next season while work on their new stadium is completed, have been given an away opener - starting their second successive campaign at Newcastle.