The two clubs collided in a FA Cup fixture late last year when Gunners midfielder Samir Nasri appeared to tread on Hull striker Richard Garcia's foot - the incident followed on from the season prior when Arsenal skipper Cesc Fabregas allegedly spat at Hull assistant Brian Horton after the match.
But Wenger says there will be no special fuss made about it as it just another game in a very long season.
"We don't make a special fuss of anything, we just try to play football. I respect everybody in life, and I don't make any special issue of that," he told The Sun.
"We have to focus on what is the most important, which is that the people who pay to come to watch a football game get something for their money. That is what we always try to do.
"We do not focus on bad blood. We just focus on our game and try to play well.
"In fact, if you look at what happened - there was not a lot. Nobody has been injured, there was a little brawl at some stage where we got punished, them as well, but the game was not dirty."