Taylor could be out for up to six months with cruciate knee ligament damage sustained early on in last Thursday's Europa League clash with Atromitos - while Simpson limped out of Sunday's 1-1 Premier League draw against Aston Villa with a hamstring strain.
"The main aim's to get a starting XI spot," he told the Evening Chronicle. "I want to be a Premier League starter for Newcastle. That's my aim, to work hard and give the manager a headache.
"I'm waiting for my chance, and when the time comes, hopefully I'll take it. I'm comfortable in all positions - left-back, centre-back and right-back. I'll work hard in all the positions that I can play.
"I'm ready to play wherever the gaffer wants me. It's just a matter of getting my chance in the Premier League."