The Frenchman enjoyed a mixed season in his debut campaign for the Red Devils, but Neville believes the 23-year old will be fresher after having no tournament commitments this summer.
"I think United will be getting a fresher Pogba this season, especially as he's got one year of the Premier League under his belt," Neville told Sky Sports.
"He'll know more about what's required and we'll see big things from him.
"He's the player I'm most excited about.
"If he takes a game by the scruff of the neck, he can be as good as the best midfielders in the world."