Neville does accept results between the major contenders can have a significant effect, even if United landed a record-equalling 18th league championship last term despite winning just once against the established 'big four'.
"These matches are always key," he said.
"It is a big game between two big clubs. Both teams will want to win, but both also know it will be just as difficult as ever.
"No matter what happens though, there is still a long way to go."