The Red Devils host the Portuguese outfit at Old Trafford in Champions League Group C action and the winger sees the match being won and lost in the centre of the pitch.
"I think their strongest point is their midfield. If we are able to control the midfield, then I am sure we have a good chance to have a positive result," Nani said.
"I'm sure Benfica will play some good football but with a lot of care as well because they know they are playing away at our ground. We will do our best to get the positive result that we aim for."
"My record is okay - I lost one game, won one game, drew another. Of course I used to enjoy it when we beat Benfica. I hope I can win again this time."