Pogba was United's big summer signing and while the Frenchman made a stunning debut against Southampton, his performance in the Manchester derby on Saturday has been widely slammed.
Many have criticised Pogba for not having much of an influence on the game but former United defender Neville has gone on to defend the 23-year-old by stating that Mourinho should have used the midfielder in a more suitable formation.
Neville said on Sky Sports' Monday Night Football: "The way Pogba played was not surprising.
"In all the time that he's played for Juventus, he's played in a midfield three, he's not someone you would play in a two in midfield because he doesn't have the discipline.
"You wouldn't want him to be disciplined. His strength is getting forward.
"In big games Mourinho will have to look at the set up of his midfield. I think he has to play Pogba further up - he had a similar problem with (Cesc) Fabregas at Chelsea - and go with a three in midfield."