Milito scored twice at the Stadio Barbera, but his side were beaten by a motivated Rosanero in Sicily.
"It's not right to think of the Inter of two years ago,” the Argentine international striker, who was part of that treble-winning side, told RAI.
“Today we are a different team, with a new Coach who has other tactics in mind compared to those of the past and we have to be able to adapt to it.
"On a personal level it is always gratifying for a striker to score, but I can't hide my disappointment at the result.
“Naturally we all want to win, but now it's time to look to the future and try to improve."