Middlesbrough's 20-year-old defender Matthew Bates will be sidelined for months after managing just 25 minutes of football on his return from serious injury.
Southgate said: "We all feel for Matty, who was looking forward to playing football again after a long period on the sidelines.
"He had applied himself so well to get back in contention and this latest injury is obviously difficult for him to accept.
"He will get the best possible medical support from us as far as treatment and rehabilitation are concerned and we are all right behind him at this difficult time."