With the 23-year-old definitely unavailable for Tottenham's trip to the Riverside Stadium it has been suggested this weekend could be a good time for Boro to face Mauricio Pochettino's side.
"I think we would miss Alvaro [Negredo] more than they will miss Harry Kane," Karanka told his pre-match press conference.
"They have really good players and much more players to play. They have an amazing squad.
"Mauricio will put in another player - maybe not as good as Harry Kane - but the player who plays will be very motivated because he has his chance."