The Hoops meet the Accies at New Douglas Park on Sunday and McDonald knows they will be out take a scalp and push themselves away from the relegation zone.
Hamilton have recorded just five points from eight matches this term but that fact does not say a win will be any easier according to the Australian international.
“We know they will be out to beat us, just like every other team when we play them away,” McDonald told tribalfootball.com.
“The important thing for us is that we remain calm and patient and do our best to get three points so we can stay within striking distance of the top side.”
You can also catch the Hamilton v Celtic match live later that day at 11:25pm.
As well as the Scottish Premier League, Setanta Sports has a feast of football from around the globe for your viewing pleasure.
Friday 23rd October
10:45am Copa Sudamericana Fluminense vs Universidad de Chile LIVE
Sunday 25th October
12:55am SPL Rangers vs Hibernian LIVE
2:55am Serie A Sampdoria vs Bologna LIVE
5:55am Ligue 1 Rennes vs Montpellier LIVE
8:30am Ligue 1 Bordeaux vs Le Mans
10:15am Bundesliga Bayern Munich vs Frankfurt
9:45pm Russian Premier League Lokomotiv vs Saturn
11:25pm SPL Hamilton vs Celtic LIVE
Monday 26th October
1:25am Bundesliga Hertha Berlin vs Wolfsburg LIVE
3:25am Bundesliga Schalke vs Hamburg LIVE
6:40am Serie A Chievo vs Milan LIVE
9am Eredivisie AZ vs Ajax
10:45am Ligue 1 Marseille vs PSG
2:15pm Russian Premier League CSKA Moscow vs FC Moscow