Led by Australian international striker Scott McDonald, the Hoops will be desperate to avenge the title loss of last season and kick-start their campaign of redemption with a big away win.
McDonald will joined by New Zealand national team forward Chris Killen who has been in brilliant goal scoring form during pre-season.
Elsewhere in the UK, Nick Carle will be hoping for some game time with Crystal Palace who meet Bristol City at Ashton Gate in England's Championship whilst Middlesbrough defender Rhys Williams and goalkeeper Brad Jones will be intent on keeping a clean sheet against Swansea City at Liberty Stadium.
In England's League One, former Melbourne Victory shot-stopper Michael Theoklitos may find himself on the substitutes bench after letting in seven goals against Colchester United on debut, especially after Tottenham loanee Ben Alnwick kept a clean sheet in the Carling Cup against Yeovil Town midweek.
Leeds United recruit Patrick Kisnorbo will be buoyed by representing Australia in Ireland on Wednesday and will be doing his utmost to keep Wycombe Wanderers quiet as Neil Kilkenny will be busy in midfield in the clash at Adams Park.