"Louis is different to anyone else we have at the club. He can be unplayable," Neville told the Daily Star.
Saha prepares to start his first match since February 27 at Everton on Saturday. Neville, out since March, stressed what a key player Saha is when 100 per cent fit.
He said: "We could see what a difference he made when he came on against Sunderland.
"If he can stay clear of injuries then we have a great centre-forward on our hands."