Giggs, who will become United's joint all-time appearance maker alongside Sir Bobby Charlton if he plays at Wigan, said: "It's in our hands, which is all you can ask for."
Speaking on MUTV, he added. "It's going to be a tough game. Wigan have got some decent players. They showed that when they played Chelsea and got a draw.
"But no matter what happens with Chelsea, it's still in our hands and we've got to be professional and do our job."