Last season's quarter-final tussle between the pair was scarred by violence, with fighting marring both legs.
"That will be the talking point after last season," said Ferguson.
However, the United boss also has other major challenges to ponder, not least a testing trip to Dynamo Kiev and two encounters with Sporting Lisbon, the club which provided the Red Devils with both Cristiano Ronaldo and Nani.
"It is a very tight group," he added. "Dynamo Kiev are a good side.
"We also have two of Sporting Lisbon's former players, so we know a bit about them."
Ferguson will hope to avoid a repeat and has already set his side the task of gaining 10 points to get them on the road to bettering last season's semi-final berth.
"The whole group possesses some very interesting aspects," he said. "We hope we can get 10 points. It will be difficult but if we can get that I think we will qualify."