Last season's quarter-final tussle between the pair was scarred by violence, with fighting marring both legs.
The trouble overshadowed one of the finest European performances of all-time by Sir Alex Ferguson's men, who thrashed the Serie A outfit 7-1 at Old Trafford after losing the first leg 2-1.
"That will be the talking point after last season," said Ferguson.
However, the United boss also has other major challenges to ponder, not least a testing trip to Dynamo Kiev and two encounters with Sporting Lisbon, the club which provided the Red Devils with both Cristiano Ronaldo and Nani.
"It is a very tight group," he added. "Dynamo Kiev are a good side.
"We also have two of Sporting Lisbon's former players, so we know a bit about them."
Ferguson will hope to avoid a repeat and has already set his side the task of gaining 10 points to get them on the road to bettering last season's semi-final berth.
"The whole group possesses some very interesting aspects," he said. "We hope we can get 10 points. It will be difficult but if we can get that I think we will qualify."