After being substituted during the latter stages of Manchester United's win over Middlesbrough, reports emerged that Ferdinand had been sent for a scan following the recurrence of a groin problem that saw him miss two key England games against Brazil and Estonia at the end of last season.
"I don't know where the reports have come from, I have been training fully this week so there is no problem," Ferdinand told MUTV.
"I got subbed after 75 minutes at the weekend and the manager said it was just to rest me, which I hope was true.
"I have been training hard this week and have been getting ready for the game."
Although Paul Scholes is definitely out, Owen Hargreaves' return to action balances that setback, while Michael Carrick is also expected to be available after dislocating an elbow against Roma earlier this month.
Without question, it is the biggest game of the domestic campaign so far, although, at such an early stage, Ferdinand doubts whether it could be dubbed a title decider.
"It will be a good statement if we win but I don't think it will be an outright yes that who wins the game will win the league," said Ferdinand. "We need to make sure we give a good account of ourselves and get the points to keep us at the right end of the league."
No matter what the outcome, few expect United to maintain their free-scoring form.
Having equalled a 100-year-old record by netting four times for the fourth successive game last weekend, with Ferdinand on target against both Aston Villa and Dynamo Kiev, Ferguson would no doubt accept a return to the single-goal triumphs that characterised the early stages of his side's current victorious streak.
"We have been scoring a lot of goals recently which is a big difference to the start of the season," said Ferdinand.
"We seem to be putting them in the net now and that bodes well.
"We have got to continue and sustain it over a long period of time, if we can be in this position after the Christmas period then we will be in a great position."