Following a busy international break playing for Portugal, including a home draw against Jonny Evans' Northern Ireland, the Reds winger is hoping to return to domestic action against the Potters and is confident his team-mates can prevail against Tony Pulis' side.
"It is always hard to play against Stoke because they play a different kind of football to most teams in the Premier League. They are very physical and have very strong players," Nani told ManUtd.com and MUTV.
"It is also difficult because most of the game is in the air. We need to be strong and try to play our game. We are playing at home and we have to believe we can win the three points. It is very important because when you play at home, you have a good chance to win these games."