The England striker was sent off when United lost at Craven Cottage last season.
And when the champions went to Fulham in December, an under-strength team was humbled 3-0.
Rooney admitted: "It will be different circumstances this time when we play Fulham and we really owe them one.
"This is a massive part of the season for us and we are really coming into form. We know it's going to be a tough game because they have had another good season, but we're happy with how we are playing at the moment.
"I've heard it said Arsenal have got the easiest run-in, but there are no easy games in the Premier League. At this stage of the season, it doesn't matter whether you play a team at the top or the bottom - everybody is fighting for something.
"I am sure there will be testing games for everyone before the end of the season. I don't think anyone can say they've got an easy run-in.
"But to beat a team like AC Milan 4-0 and to score seven goals against them in two matches is going to give us a lot of confidence over the coming weeks."