The Red Devils take on Scottish giants Glasgow Celtic in the first of five matches which will take in Canada, the USA and Mexico.
Following the Celtic clash which kicks off at 7pm ET, Sir Alex Fergusonâ€™s men will meet MLS expansion franchise Philadelphia Union, foundation club Kansas City Wizards, the MLS All-Stars and Mexican outfit Chivas Guadalajara.
United have been in Chicago since earlier this week and held a training session at Toyota Park as well as an interactive fan event at the Niketown store.
They left for Toronto on Thursday and following their stay there will move onto Philadelphia, Kansas City, Houston and Guadalajara.
Full Tour Schedule
July 16: Manchester United vs. Celtic F.C. (7 p.m. ET, Rogers Centre)
July 21: Manchester United vs. Philadelphia Union (7:30 p.m. ET, Lincoln Financial Field)
July 25: Manchester United vs. KC Wizards (6 p.m. ET, Arrowhead Stadium)
July 28: Manchester United vs. MLS All-Stars (8:30 p.m. ET, Reliant Stadium)
July 30: Manchester United vs. Chivas Guadalajara (Guadalajara, Mexico)