The Manchester United star made it five goals in Group D qualifiers by netting in the 55th and 65th minutes to send the Oranje seven points clear of second-placed Hungary with 18 points from six outings.
Hamburg’s Rafael van der Vaart opened the scoring in the 11th minute when he finished van Persie’s pass from the right from 18 yards before the latter doubled Holland’s advantage in Amsterdam ten minutes into the second half by heading home Arjen Robben’s leftwing cross at the front post.
The former Arsenal captain gave his side an unassailable lead after the hour-mark by converting a penalty which was won by Jeremain Lens before the PSV Eindhoven man put the result beyond doubt with a late fourth goal.
Louis van Gaal’s Dutch side are now odds-on favourites to finish on top of their group with bottom sides Estonia and Andorra to come in the next two matches (in September) before a home clash with Hungary and a trip to Turkey (both in October) to round out proceedings. Romania find themselves third in the group with 10 points from six outings.