Both Dutch ace van Persie and England forward Rooney have been struggling with groin problems and Moyes is crying out for them after his side lost 2-1 to Swansea City in the third round of the FA Cup on Sunday.
"It'll be great when we get them back, the sooner we get them back the better. They're not ready yet," he told BT Sport.
"If you lose games at any club, it's difficult. At Manchester United it's even bigger, but that's the job and we get on with it."
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